The technology of prevention and control of water pollution is one of the important research topics of polluted water treatment.Taking the aeration treatment being one of sewage treatment process for example, the method of 3D computer simulation was used to inquired into the aeration efficiency in different aeration pipe number, and a more reasonable conclusion was got, the aeration of three four holes aeration pipe in the aeration tank had the best effect,the result has important significance in theory and practice.