Reclaimed water irrigation can effectively alleviate agricultural water scarcity; however, reclaimed water contains endocrine disrupting compounds(EDCs) that can leach into the soil during irrigation. We carried out a soil box simulation test to clarify the temporal and spatial patterns of typical endocrine disruptors in soils under drip irrigation with reclaimed water. We investigated the distribution and accumulation of a typical endocrine disruptor named nonylphenol and its isomers in soils under drip irrigation with reclaimed water, analyzed their migration and degradation processes at different soil depths, and proposed the mass balance law of nonylphenol in soil. The results showed that nonylphenol in soil presented a trend of increasing and then decreasing at different soil depths. The degree of accumulation and distribution of nonylphenol isomers varied in soils at different depths, with contents of NP3, NP2, NP11 and NP12 higher than those of NP1, NP7 and NP8. Under drip irrigation conditions, the attenuation rate of nonylphenol for clear water irrigation was 48.40%,; whereas that for reclaimed water irrigation ranged from 69.18% to 98.50%, and the attenuation rate of nonylphenol in soil increased with increasing concentration of reclaimed water.