With the development of economy and society, water resources system is challenged by aggravating risks. Exploring the resilience of water resources system is of great essentiality for the rational use of water resources and sustainable development of water resources. According to the actual situation in Xinyang City, 18 evaluation indexes were selected from the three aspects of resistance, recovery and adaptability to construct the evaluation index system of Xinyang City’s water resources system resilience. The weight of each index was determined by the entropy method, then fuzzy comprehensive evaluation, grey relational analysis and technique for order preference by similarity to an ideal solution (TOPSIS) were adopted to evaluate the water resources system resilience of Xinyang City from 2012 to 2021 from three aspects, namely, the evaluation object’s merit rating, the correlation between the evaluation object and the optimal solution, and the proximity between the evaluation object and the optimal solution. The results show that the fuzzy comprehensive evaluation method can better define the evaluation criteria of water resources system resilience. According to the evaluation results of this method, the water resources system resilience of Xinyang City from 2012 to 2021 is mainly at level Ⅱ and Ⅲ, exhibiting a general increasing trend, but there is still room for improvement.