In order to obtain an accurate irrigation quota suitable for drip-irrigated spring maize in the northern Xinjiang, six levels of irrigation quotas of W1 (225 m3/hm2), W2 (300 m3/hm2), W3 (375 m3/hm2), W4 (450 m3/hm2), W5 (525 m3/hm2) and W6 (600 m3/hm2) were set to study the effect of irrigation quotas on growth and yield of spring maize. Some growth, yield and water-saving indices were selected as evaluation indices to analyze the law of water consumption and significance of different indices, then the entropy weight-TOPSIS comprehensive evaluation method was used to optimize the irrigation quota suitable for drip-irrigated spring maize in the northern Xinjiang. The results show that the key fertility period for drip-irrigated spring maize is the tasseling pollen period, and the optimal irrigation quota for this period is 525 m3/hm2; the growth rate of water consumption and intensity of water consumption decreases significantly after the irrigation quota reaches 525 m3/hm2. According to the significance analysis of each index, the irrigation quota of 450-525 m3/hm2 is more suitable for the growth of spring maize in the northern Xinjiang. The results of the comprehensive entropy weighted-TOPSIS evaluation show that the highest closeness and the best evaluation results can be achieved when the irrigation quota is 525 m3/hm2, at which time the maize yield is about 16, 178.71 kg/hm2. Therefore, we recommend 525 m3/hm2 as the optimal irrigation quota for drip-irrigated spring maize in the northern Xinjiang.