Quantifying the economic efficiency of water consumption of different crops is the premise for the regulation of agricultural water consumption by economic means. Based on the water footprint theory, we simulated the blue water footprint and production water footprint of main crops in the upstream of Xiong’an New Area, and evaluated the economic efficiency of the water footprint in combination with statistical data. Then, the simulated results were verified by the survey data. The results show that in the period of 2001-2016, the blue water footprints of wheat, maize, soybean, peanut and cotton ranged from 384 to 4, 611 m3/hm2; the production water footprints ranged from 4, 122 to 6, 453 m3/hm2; the economic efficiency of blue water footprints ranged from 1.15 to 19.29 yuan/m3; and the economic efficiency of production water footprints ranged from 0.38 to 2.02 yuan/m3. There was no significant difference in the economic efficiency of production water footprint of different crops under different hydrological year types, but the difference of economic efficiency of blue water footprint was very significant, especially for maize and soybean. In terms of spatial features, the economic efficiency of water footprint in western mountainous area was lower than that in eastern plain area. However, there was a certain gap between the simulated value of the model and the economic efficiency of the water footprint in the actual production process, which was mainly caused by the difference of the water footprints.