Clarifying the infiltration volume of the Baiyangdian Lake to the groundwater is crucial to the establishment of ecology-water city in Xiongan New Area. Currently, the isotope test, long time series monitoring of water table and water temperature are used to calculate the recharge volume of the lake to the groundwater. However, these methods are costly and have certain limitations. Here, we used four representative artificial sweeteners (AS) as anthropogenic tracers, namely acesulfame (ACE), sucralose (SUC), saccharin (SAC) and cyclamate (CYC), the spatial distribution of which in surface water and shallow groundwater were described, and then the time series of ACE in the Jinlongdian Lake were used to calculate the lake’s recharge volume to the groundwater considering its recharge and discharge characteristics and the climate monitoring data. The average contents of ACE, SUC, SAC, and CYC in the groundwater were 0.11, 0.14, 0.04, 0.05 μg/L respectively, whereas those in Baiyangdian Lake were 1.16, 2.17, 0.21, 0.38 μg/L respectively. The concentrations of ACE were in the range of 0.73-1.31 μg/L in the Jinlongdian Lake during the monitoring time, and its recharge volume to the groundwater was 7.5×103 m3/d, the annual recharge volume was 2.7375×106 m3. This result demonstrates that the water environment of the Baiyangdian Lake and the groundwater in the south part of the study area are significantly affected by anthropogenic activities, and therefore these regions should be protected and restored in the future. Baiyangdian Lake is the main recharge source of the groundwater, it has a significant effect on the volume and quality of the groundwater. The accurate description of the interaction between the Baiyangdian Lake and the groundwater can provide scientific support for the management of water resources in Xiongan New Area.