Based on the time series characteristics of different land use types and object-oriented segmentation methods, the spatial-temporal patterns of land use and land cover (LUCC) in the Yellow River Delta from 1985 to 2018 was analyzed, and the related driving factors of the dynamic changes were discussed. The results show that the area of natural wetlands in the study area has decreased significantly during this period, with a total decrease of 9.984 7×104 hm2, especially the marshes and meadow wetlands. However, the area of constructed wetlands has gradually increased, with an average annual increase rate of 54.66%, which is mainly dominated by the growth of the salt farms and rice planting area. As for the driving factors of the changes in LUCC, socio-economic factors weighed more than hydrological factors in the study area. The amount of sediment transport was the major hydrological factor affecting the LUCC changes in the study area and the decrease in measured runoff accelerated the conversion of the natural wetlands to dry lands. It is found that the changes of population and GDP are positively correlated with the increase of constructed wetlands in this area, but negatively correlated with the decrease of natural wetlands.