In order to study the seperation and removal of cadmium (Cd) from sludge, the morphological distribution and content change of Cd in sludge were analyzed using the combination of ethylene diamine tetraacetic acid (EDTA) eluting centrifugation and solidification of sulfate-reducing bacteria (SRB) method. The results showed that after EDTA eluting centrifugation under the conditions of centrifugal force 100 g, washing time 12 h, washing twice and centrifugation temperature 30 ℃, the Cd content in the sludge decreased from 6.793 mg/kg to 5.241 mg/kg, and the removal rate reached 22.8%. SRB was then used to solidify the sludge after the washing and centrifuging. The content of unstable Cd reduced from 2.589 mg/kg to 1.103 mg/kg, which was lower than 2 mg/kg, the standard of grade IV according to the requirement of heavy metal content in greening planting soil (CJ/T 340-2016). Compared with the conventional single remediation method, the combined method can effectively reduce the content of Cd of high activity and pollution degree in the sludge, and alleviate its threat to the environment.