Water and fertilizer utilization efficiency in Hexi Corridor is low and the technical parameters of drip irrigation under mulch film need to be improved. In view of this situation, maize field experiments under different irrigation technical parameters were carried out in Hexi Corridor area to explore the changing law of yield, water consumption, and water use efficiency. Different dripper discharges (2.0 L/h, 2.5 L/h, and 3.0 L/h) and irrigation frequencies (6 d, 8 d, 10 d, 12 d, and 14 d) were set. According to the experiment results′ it was found that the water consumption of maize showed a trend of increase-decrease-increase with the decrease of irrigation frequency. Low-frequency irrigation with large dripper discharge would increase water consumption. With the increase of the dripper discharge, the water consumption showed a trend of increasing first and then decreasing. With the decrease of irrigation frequency, maize yield and water use efficiency increased first and then decreased with the maximum value occurring after 8-10 days′ irrigation. Maize yield and water use efficiency were both at a low level under the 2.5 L/h dripper discharge, and the water use efficiency decreased first and then increased with the increase of the dripper discharge. Therefore, when the irrigation frequency is relatively high (6-8 d) or low (14 d ), the drip irrigation belt of 2.0 L/h or 2.5 L/h should be selected. When irrigating at a medium frequency (10-12 d), the drip irrigation belt of 3.0 L/h should be selected.