Environmental change is the main factor leading to the disturbance of hydrological processes in a river basin, the evaluation of which is of great importance to the formulation of water resources planning and management strategies. Non-parametric Mann-Kendall test and Pettitt test were used to diagnose the variation trend and abrupt changes of the runoff in the section of Shizhandao Station. Based on hydrological and meteorological data, the VIC model was set up to simulate runoff processes. The influence of environmental change on annual runoff was quantified during different human activity period. The results showed that the runoff of Shizhandao Station presented a decreasing trend, and the abrupt change year appeared in 1979; based on which, the study period was divided into runoff base period from 1959 to 1979 and two change periods, namely 1980-1991 and 2006-2015. The model had a high applicability to the research area, and both the Nash-sutcliffe efficiency coefficient and relative error met the requirements of more than 0.75 and less than 10%. During 1980-1991 and 2006-2015, the impact of climate change and human activities on runoff reduction were 14.4%, 85.6%, 15.4% and 84.6%, respectively. Human activities were the main driving force of runoff change of Shizhandao Station.