In order to comprehensively evaluate the state of regional human-water harmony, 16 indicators are selected from three aspects, which are human system development, water system health and human-water system coordination, to construct an evaluation system. Then a series of evaluation index grading criteria are determined to establish a human-water harmony evaluation model based on normal cloud. This model uses game theory to determine the individual comprehensive weight of each indicator, and normal cloud generator to determine the indicator membership, based on which the harmony level of the indicator is decided according to the principle of maximum membership. We adopted this model to evaluate the human-water harmony in Suqian City from 2013 to 2017. The evaluation results show that the overall human-water harmony in Suqian City is on the rise, and some disharmonious indicators have great potentials for improvement. These foundings are consistent with the actual situation, indicating that the propcsed evaluation model is applicable. At the same time, the evaluation results and related suggestions can help Suqian City further coordinate the relationship between human and water.