The Danjiang and Hanjiang River Basin, located in the middle and upper reaches of the Hanjiang River, is the main water source of the Danjiangkou Reservoir. Its water quality determines the success or failure of the National South-North Water Transfer Project. Therefore, the study of non-point source pollution in this basin is of grave importance. By reviewing the literatures, we summarized the transport characteristics of sediments and nutrients in different spatial scales in the basin, compared various load estimation methods and model application progress of the non-point source pollution, and expounded the control measures of water, soil and nutrient loss, as well as the research progress of ecological compensation from three aspects of the source, process and end control. It is found that the sources, process and transport characteristics of current non-point source pollution are still unclear. There are few application models and even fewer models developed by individuals, and the pollution control and management measures are scattered. In the future, it is necessary to continuously strengthen the systematic monitoring of data, to identify the types, sources and loads of non-point source pollution in the basin, as well as to improve the type and accuracy of the application models, so as to establish optimal development and management methods for the land and water in watershed, and improve the quantification research and control system.