The organic acid has the advantages of slow speed and low corrosion, and it forms a main acid in combination with HCl (hydrochloric acid). The main acid combines with additives such as corrosion inhibitors to form a working fluid system with conventional acids suitable for low permeable limestone water wells. Through the physical and chemical analysis, static dissolution rate, core flooding and static corrosion experiments of the Zigui Baota formation limestone, the working fluid system was comprehensively evaluated. The results showed that the average dissolution rate of HCl on rock powder after 0.5 h, 1 h and 1.5 h was 95.1%, and that of HAC (acetic acid) on rock powder after 1.5 h, 3 h and 4.5 h was 83.5%. The dissolution rate of "8% HCl +6% HAC" after 4.5 h was 97.0%. The core flooding experiment of "8% HCl +6% HAC" on Baota formation limestone core showed that the permeability of the rock sample increased 270-1300 times after acidizing. The minimum breakthrough volume of the acid solution was 343.6 pore volume(PV) when the acid injection rate is 1 mL/min. The imidazoline corrosion inhibitor can be used as both retarder and corrosion inhibitor, which can retard the reaction of acid with limestone and reduce corrosion on the drill. The acid fluid system can effectively increase the permeability of the limestone aquifer thereby increasing the well production and helping to solve the geological problems of the livelihood in some water-deficient areas.