Evaluation of water resource security is important for the management and planning of water resource. This study established integrative assessment system using the entropy value method and analytic hierarchy process method, and analyzed status of water resource security for Guangdong Province during 2007 and 2016. Results showed that security index of water resource ranged between 0.4 and 0.6 for Guangdong Province in the studied 10 years, which belonged to general security level. The security index for water resource and community economy increased, whereas the security index of water ecology decreased. Moreover, the spatial pattern of security index of water resource displayed significant heterogeneity, with the lower security class of water resource distributing in the Pearl River Delta region, eastern (Chaoshan) and western (Zhanjiang) part of Guangdong Province. The security index of community economy decreased from the Pearl River Delta region to outside. Furthermore, the effects on security of water resource showed obviously spatial differences. The advantage of water resource security in the Pearl River Delta region was community economy, while the disadvantage was water ecology. For the eastern, western and northern parts of Guangdong Province, the advantages were water resource volume and water ecology, while the disadvantage was community economy. In conclusion, the spatial pattern of water resource security and economic development did not well correspond, and the status of water resource security was relatively worse in the Pearl River Delta, eastern and western parts of Guangdong Province. The results will be beneficial for the management and planning of water resource in Guangdong Province.