Hydrology experiment is of importance to understand hydrological laws. According to the observed data of Chengxi experimental watershed located in the eastern low hilly area of China, responses of runoff to rainfall variation at different scales were analyzed. The feasibility of the Xin'anjiang model to low hilly area of China was verified using the hydrological simulation approach. The results showed that: At experimental watershed scale (tens of square kilometers), discharge peak time usually lags 3-4 hours from storm peak time. Runoff highly correlated to rainfall at both event-and month-scale whereas the weak correlation was found at daily-scale, the scatter points of daily runoff to rainfall presented a U-type distribution with rainfall thresholds of approximately 10 mm and 70 mm. Runoff was extensively influenced by antecedent hydrological recession at three time scales, with higher influence at shorter scale. The Xin'anjiang model can generally reproduce hydrological process of the eastern low hilly area with a better performance at monthly scale, and the simulation of natural watershed is better than that of human disturbed watershed.