Global climate change has changed the current situation of water resources. The study of climate change is particularly important in the source regions of the Yellow River due to its dry runoff. In order to study the characteristics of climate change in the source regions of the Yellow River, temperature and precipitation data from 12 national weather stations from 1960 to 2016 in the past 60 years were selected to comprehensively analyze the annual and interannual climate change characteristics with the methods of the ordered clustering, Mann-Kendall test, sliding T, linear fitting, Spearman and Morlet wavelet methods. The results show that the growth trend of the average temperature in the four seasons is significant with the largest increase in winter. Precipitation in spring and winter shows a significant growth trend, while no significant downward trend in summer and autumn. The abrupt change of annual average temperature is found in 1997 , whereas there is no obvious abrupt change of precipitation. In addition, the temperature has an obvious increasing trend, while the precipitation sequence shows no obvious increasing trend. The climate change interval analysis reveals that the annual average temperature fluctuates significantly with the intervals of 10, 5 and 23 years, and the annual precipitation fluctuates with the intervals of 28, 11 and 8 years, respectively.