Ningdong energy and chemical industrial base is an area with acute shortage of water resources, how to reasonably allocate the water resources is vital to the development of the industrial base. In this paper, the water resources of Ningdong energy and chemical industrial baseare optimized using linear programming model, a plan of conjunctive use of surface water and underground water was proposed. In the plan, the actual quotas and routes of groundwater supply were also determined and the following conclusions were drawn . The Pingluo fine chemical base was supplied by water resource Taolebang River with 0.065×108 m3/a, Hengcheng and Yuanyanghu chemical base was supplied by Luotuojingemergency water resources with 0.019×108 m3/a, Lingwu industrial and mining areas was supplied by water resources of No. 2 and 3 chemical base with 0.089 108 m3/a and 0.067×108 m3/a on Wuzhong plain; Majiatan and Jijiajing industrial and mining areas was supplied by No.1 water resource in Daquan area with 0.054×108 m3/a. The groundwater was jointly allocated according to the total groundwater supply of 0.294×108 m3/a and the optimal supply route, and the quota of surface water was only 3.136×108 m3/a, which can not only meet the water resources demand of Ningdong energy chemical industrial base in 2020, but also maximize the social, economic and environmental benefits.