In order to study the relationship between macro-structure of loess and collapsibility coefficient, the loess collapsibility tests of Xinjiang's undisturbed loess and disturbed loess from various depths have been carried out under the condition of adding or reducing moisture. The collapsibility curve's variable features over initial water content have been reached based on the study results, and the relationship between macro-structure and loess collapsibility coefficient has been analyzed from the perspective of static potential energy. Collapsibility coefficient represents the macro-structural differences derived from saturation between original loess and saturated loess of unit thickness. Based on collapsibility coefficient, the paper discussed loess structural "stability" and "variability"， and obtain the change rules along with initial water content. Collapsibility coefficient is more suitable at describing the change of the loess structure, and the tendency of loess structural "stability" and "variability" in various conditions could be analyzed.