In order to study the complete limestone rocks' permeability evolution law during the process of erosive fluid infiltration, three different penetrant experiments of the limestone core under the conditions of chemical erosion and stress of the infiltration solution were designed. By measuring the flow rate of exudate and the ion concentration contained in the exudate at different times in each working condition, the main influencing factors and evolutionary mechanism of the complete limestone permeability were analyzed. The experimental results show that the infiltration of liquid and the application of stress have diverse effects on the evolution of rock permeability. At the beginning of the experiment (0 ~ 50 h), since the pressurization (surrounding pressure, axial pressure, osmotic pressure) has a time-dependent permeability to the core, the core permeability decreased sharply under the three conditions, and stress effect was the main factor that caused the change of rock permeability. As the experimental process progresses, the pore throat inside the core gradually closes. The chemical erosion of the permeable liquid began to appear after about 50 h. In subsequent 330 h, the permeability of the core was basically stable if penetrant was distilled water. When the permeation solution was sodium sulfate solution or sulfuric acid solution with pH = 6, the core permeability decreased continuously which indicated that at the end of the experiment chemical erosion played a key role in the evolution of core permeability. In the three working conditions, ion dissolution happened in the core exudate all the time, but different permeation liquids had different dissolution effects on the minerals of the core, with significant changes in exudates of ion concentration and ion concentration ratio. When there were components promoting the dissolution of the mineral and a low osmotic pressure in the permeate solution, the ions gradually accumulated but cannot be transported out of the core in time, which caused precipitation to block the core permeation channel. During the experiments, the evolution of permeability of the complete limestone is a result of the combined action of erosion of the permeate solution, stress interaction and the solute precipitation.