Taking the bank slope of the Lengqing Highway in Yunnan as the research object, a two-dimensional saturated-unsaturated seepage model of slope in reservoir is built,and is used to simulate the seepage regular pattern of shore slope under different conditions after anchor and pile reinforcement. The changing rule of the infiltration line and pore water pressure after the reinforcement of the bank slope is analyzed. Results show that the shape and location of infiltration line and the distribution of pore water pressure in the reinforced reservoir slope have changed compared with no reinforcement slope, as the seepage resistance increases and the seepage path changes in the reinforcement area. Compared with the case of anchor reinforcement, the seepage resistance effect of the pile is less than that of the anchor reinforcement. The pore water pressure in the bank slope is controlled by the water level fluctuation, the distance from analyzed location to the reservoir or the infiltration line, the decrease degree and area and shape of osmotic coefficient, and the lag effect of the reinforced bank slope is more obvious. In the position far away from reservoir surface, the pore water pressure is almost not affected by the water level and reinforcement measures.