The spatial variability of the hydraulic conductivity of floodplain sediments is of great significance to the restoration and protection of ecological environment in the basin. In order to study the spatial variability of the hydraulic conductivity of the floodplain sediments, using double loop test method and standpipe test method, we selected 6 unsaturated test sites and 138 saturated test sites in total for the six test sections of the Lintong section of the Weihe River, respectively. All data were analyzed by geographical statistics method. We found that the hydraulic conductivity coefficients of the unsaturated zone and the saturated zone in the Weihe floodplain are between 1.30 m/d -6.08 m/d and 0.002 m/d-1.763 m/d, respectively. The results show that: the unsaturated hydraulic conductivity of the floodplain sediments in the Lintong section of the Weihe River is large and the saturated hydraulic conductivity is small; the saturated hydraulic conductivity of the floodplain is consistent with the normal distribution along the river and the variability is strong. The spatial correlation of the saturated hydraulic conductivity of the floodplain is weak, but both have spatial autocorrelation. The results provide theoretical and data support for the study of surface water and groundwater conversion in Weihe River Basin.