With the reduction of fresh water resources and the increase of energy demand, the uncertainty of food supply has become more serious. Taking Jiangsu Province as the research object, in this paper the evaluation index system of water- energy-food (W-E-F) system interconnections was established,by using the entropy method the weight of each index was calculated,the coordinated development level was evaluated quantitatively by coupling coordination model , and then based on the gray GM (1.1) model the coupling coordination degree in the next five years was predicted. The results show that, the comprehensive evaluation index of W-E-F system in Jiangsu Province showed increasing trend over time from 2000 to 2015. The coupling degree kept a high level, the coupling coordination degree was inverted “U” curve, experiencing three stages of primary coordination, reluctant coordination, and intermediate coordination , and further raise to high level of coordination in the next five years. However, the level of development of water resources and energy still lags behind that of food. Therefore, the efficiency of water and energy use is enhanced so as to promote the sustainable development of the region.