Groundwater is the main water supply source of Haihe River Plain. In this study, 269 samples were collected from March to November of 2014 in the study area, and the concentration of arsenic was detected. The monitoring data showed that the arsenic concentrations of all the samples met the requirement of Class III water quality. The temporal and spatial variation characteristics of arsenic in groundwater in Haihe River Plain were analyzed by the geostatistic method and the results show that the degree of dispersion and coefficient of variation were high, with the trend which was high in the East and low in the West in space, and areas with high concentrations of arsenic were concentrated in Tianjin, Hebei, Bohai and central Hebei. In the temporal distribution, the spatial variability of summer and autumn was strong, the spatial variability of spring was moderate, and the spatial variability was the weakest in winter. In order to prevent the harm caused by arsenic poisoning, the relevant departments should avoid the arsenic rich sediments when selecting the groundwater exploitation wells and the upper part of the well should be properly closed.