With the rising levels of urbanization in China, the problem of urban water system has become more and more serious in recent years. Taking Jiangsu province as the research object, in this paper the evaluation index system of urbanization system process and the level of interconnected river system network were established, the entropy method was used to calculate the weight of each index, and then the coupling and coordination degrees of urbanization and interconnected river system network were calculated by using the Coupling and Coordination Model. The results showed that, the urbanization level increased year by year from 2004 to 2014 in Jiangsu province, and the level of interconnected river system network was basically declining. The urbanization and the interconnected river system network has undergone the low-level coupling stage and the resistance stage, and transitted to the basic running-in stage. The coupling and coordination degree was generally at a low level in the early stage and ascended in the later stage. As a result, attentions should be paid to the construction of urbanization and the interconnected river system network in the process of urbanization, so that the coupling and coordination of them can promote the harmony of people and water in the region.