Based on the flow characteristics of the external ocean environment and internal fluid for 1000 m deep-ocean lifting pipes, the fluid-structure interaction finite element model of the lifting pipes was established. Under the different working states, the displacement and stress distribution characteristics with different internal fluid, the buffer and the towing velocities were studied. The results indicated that, the internal fluid was an important factor, whose effects on the displacement and stress of pipes can not be neglected. With the increase of internal fluid density, the lateral displacement of the lifting pipes decreased and the equivalent stress increased. With the increase of towing velocity, both the lateral displacement and the equivalent stress of the lifting pipes increased. With the increase of the buffer weight, the lateral displacement of the lifting pipes decreased and the equivalent stress first decreased and then increased.