Through the experiments of screening fillers and the runoff treatment effectiveness of the filler optimization combination multilayer infiltration filter, the paper analyzed the adsorption properties of ceramsite, rare-earth porcelain grit, zeolite and quartz sand to runoff major pollutants COD ，Pb and Zn and studied the processing performance of rapid infiltration filter for runoff pollutants.The results showed that ceramsite, rare-earth porcelain grit, zeolite have better adsorption and ion-exchange properties for organic matter and heavy metal of runoff than quartz sand. So these three kinds of fillers were used in the runoff infiltration filter, and each kind of filler's thickness is 30 cm, with the different combinations of fillers, it would lead the obvious differences treatment effect of the runoff infiltration filter. The optimum hierarchical combination of infiltration and storage fillers from top to bottom is ceramsite, rare-earth porcelain grit and zeolite.The removal rate of COD and SS are up to 94.82%, 97.82% respectively, Pb and Zn are up to 81.05%, 75.64% respectively.The COD of treated water is about 50mg/L, SS is about 25 mg/L, Pb and Zn are all about 0.13 mg/L. For the treatment of urban runoff, the fillers optimization combination multilayer infiltration filter is more efficient than the traditional quartz sand filter.