In view of the problem of vibration propagation of adjacent unit-blocks of hydropower house, the paper used a large scale underground hydropower house as the research object,and used the prototype vibration observation data to carry out 3D numerical simulation and studied the relative law. The results showed that the middle frequency vibration loads has greater influence on the vibration of the adjacent unit-block.The foundation is one of main vibration transfer paths between adjacent unit-blocks.The result can provide support for the structural design of hydropower house.