In order to study the effects of different amount of fertilizers and rainfall on agronomic traits and yield of corn, the four treatments such as no fertilizer, organic manure, chemical fertilizer, combined application of chemical fertilizer and organic manure were selected to analyze the situation under different fertilizer controls and precipitation in Guizhou from 2010 to 2012. The results showed that kernels per spike highly correlated with precipitation and the correlation index was 0.425, the plant height had the highest correlation with fertilizer controls and the correlation index was 0.905, years of highly precipitation(888.5mm , 1031.5mm for 2010 and 2012 respectively), the corn yield was affected by interaction of precipitation and fertilizer controls, and had significant yield-increasing effect. Different fertilizer controls and precipitation had obvious effect on kernels per spike and kernel number per row, and control of MNPK in 2012 (1031.5mm)was the highest, 10%, 13% and 17%, 1% higher than that of 2010(888.5mm),2011(497.3mm),respectively, and 58%,18% higher than CK. The higher precipitation and MNPK control had significantly yield-increasing effect, in highly precipitation year of 2010 and 2012,the grain yield, straw yield and biological yield of corn, 13%,17%,15% and 18%,12%,15% higher than that of 2011,respectively.