Taking sediment leaching toxicity as an index,the paper used visual analysis, variance analysis and single factor analysis to explore the effect of quicklime, potassium dihydrogen phosphate and natural clinoptilolite synergistic reaction on stabilization of heavy metals.The results show that quicklime and potassium dihydrogen phosphate have significant influence on heavy metal stabilization, while the natural clinoptilolite has poor effect. The optimum ratios of sediment, quicklime, potassium dihydrogen phosphate and natural clinoptilolite are 100∶6∶6∶0. In this case, the leaching concentrations of Mn, Cd, Pb, Cu, Zn are reduced by 96.6%, 95.9%, 98.7%, 99.5%, 94.7% respectively.When the curing agent achieved the optimum ratios, the heavy metals leaching toxicity satisfied the standard for pollution control on the landfill site of municipal solid waste and integrated wastewater discharge standard of Shanghai.The result can provide reference for landfill disposal and recycling.