In order to provide a basis for the design of bubble columns, the paper studied two-phase flow dynamic characteristic in a bubble column by using the CFD software.It used Euler-Euler two-fluid model along with standard k-ε turbulence model and RNG k-ε turbulence model to simulate the gas-liquid two-phase in the bubble column,and took the Phase Coupled SIMPLE algorithm to solve velocity and pressure. The comparisons of velocities of gas and liquid at different heights in the middle section (y=0) of the bubble column show that the velocity distribution in the radial direction is parabolic, and the closer the position is to the vent along the depth direction, the greater the velocity is,and the vertical velocity of gas phase is greater than that of liquid phase. By comparing the vertical liquid velocities with experimental values at the height of z=0.28m, it obtained that the Euler-Euler two-fluid model combined with standard k-ε turbulent two-phase flow model is better than RNG k-ε model in simulating the dynamic characteristics of bubble columns, and the lift force has significant impact on simulation result.