Methyl tert-butyl ether (MTBE) is a potential carcinogen pollutant.This article investigated the electrochemical degradation of MTBE in wastewater by using a novel three-dimensional electrode reactor with granular activated carbon as particle electrode.The effects of electrolyte, voltage intensity and pH level on the degradation of MTBE were tested. Experiment results show that under the conditions of 25℃, electrolyte (Na2SO4) concentration of 0.2 mol, potential=10 V and pH=7.0, total organic carbon (TOC) of MTBE solution with initial concentration of 50 mmol is removed by 78% after 150 min. Compared to activated carbon adsorption and bipolar electrolysis, the three-dimensional electrode reactor can greatly improve the efficiency of MTBE degradation and carbonization. Therefor, the three-dimensional electrode reactor is an effective technology to remove MTBE contamination in wastewater and has better application prospect.