Taking Xinjiang Wulungu river basin of northwest inland arid areas for example, the paper built SWAT model about soil properties and meteorological database in wulungu river.The construction process of soil database is that by looking at the soil species in xinjiang to obtain the needed foundation soil data; by using the MATLAB programming to converse soil particle size and applying SPAW software to calculate parameters of soil moisture . The build process of weather database is that downloading the ground meteorological data in China Shared service online and to sorting the data as the required format;using swatweather. exe software to calculate precipitation, air temperature, dew point, wind speed and radiation data, while obtain the swat model weather generator parameters. The SWAT model based database built successfully laid the foundation for application of the model in this basin.