By use of MIDAS-GTS software, the paper carried out three-dimensional finite element numerical simulation for single pile in pile-soil interaction system under horizontal seismic dynamic response. With elastic damping artificial boundary, it analyzed the influence of different horizontal earthquake function , the pile length , pile diameter , pile slenderness ratio , the elastic modulus of pile , pile soil elasticity modulus and poisson's ratio of soil on horizontal displacement and bending moment of single pile. The analysis results show that the reasonable selection of pile length, pile diameter and other parameters can effectively improve the seismic behavior of single pile, at the same time, the change of the parameters of soil around piles has greater influence on the horizontal seismic capacity of single pile.