In order to predict the flow field characteristics of UV disinfection reactor and enhance the accuracy of the modeling results, the paper utilized CFD simulation method and applied Standard k-ε model, Realizable k-ε model, Low-Re k-ε model and RSM model to simulate the hydrodynamic features.The results indicated that at the place of x=0,z=1cm and x=0,z=83cm, the simulation result of z direction of the four turbulence models accord with PIV experiment data on the whole. While at x=0, z=15cm and x=0,z=64cm, the simulation result of realizable k-ε model has large deviations. The results of Low Re k-ε model and RSM model are more ideal in hydrodynamic modeling.