In order to study the treatment effect of Fenton reagent on potato starch wastewater and provide a basis for practical production, The experiment took the Static beaker experiment methods and investigated the main influence factors and the optimal reaction condition of the Fenton reagent by the single factor experimental methods. It demonstrated that the potato starch wastewater has the highest removal rate of COD at 68.43% and turbidity removal rate at 98.53% under the best conditions for the dosage of FeSO4at 0.3g/L, H2O2at 1.2g/L, the reaction time at 30min and pH at 2. The treatment effect of the method is obvious and can be used as an effective pretreatment method for potato starch wastewater.