This paper built a two-story evaluation index system by using analytical hierarchy process basis on the DRASTIC, and used two-story fuzzy evaluation to carry out groundwater vulnerability assessment in Qujing basin. The results show that Qujing basin groundwater vulnerability is separated four classes, the vulnerability of western bedrock groundwater and pore-water groundwater is high, eastern pore-water and part of karst water is middle. The evaluation results are conducive to the protection of groundwater environment.