The degradation characteristics of two typical target endocrine disrupting chemicals(EDCs), ie nonylphenol(NP) and 17α-ethinylestradiol(EE2) were dectected by gas chromatography/mass spectrometry(GC/MS). The paper investigated with the processes of ozone(O3), ozone/hydrogen peroxide(O3/H2O2), ozone/ultrasound(O3/US) through batch experiment. Also, ozone reaction kinetics for the target compounds were preliminary studied. The results indicated that the removal rates of the target compounds were enhanced considerably with the two combined processes, they increased by 9.6%~17.7% for NP, and 14.6%~23.4% for EE2. Besides, the removal rates were enhanced with the ozone dose and pH value increase. when H2O2/O3molar ratios increased, the removal rates went up firstly and then declined, and the maximal removal rate was obtained at molar ratio 0.6. Ultrasound enhanced ozone oxidation efficiency, however, the variations of ultrasonic power in the selected range (60-240W) could not lead to distinct changes of the removal rate. The ozone oxidization of the target compounds conformed to the pseudo-first-order reaction kinetics, and the rate constant was higher under the alkaline condition than under the acidic one as well as tertiary butanol-adding condition.