Hydrological simulation is an enormous challenge in ecological vulnerable areas of Loess Plateau,especially application of Hydrological model is a key issue.Kuyehe River is the first class tributary of the Yellow River, Which locates in the vulnerable areas of ecology and environment, and is an important coal base. Human activities are more frequent,the problem of water resources is more outstanding under the effects of climate change. The paper used WRB model to simulate runoff in the Kuyehe River catchment from 1956to 2008. The model and validation period were selected by analysing the trend of hydrology factors, and determining paramerers and simulating runoff.Results indicate that Nash-sutcliffe coefficient exceed 70percent. In a word, this model has advantages of concise structure and less parameters, and possesses better effect on Kuyehe River catchment and provides the basis for analyzing the influence of climate change on water resources in the future.