Aiming at the problem of manganese ion is difficult to be removed from Fe-Mn-mine wastewater,the removalle efficiency and mechanism for the manganese ions with Fenton reagent-quartz sand process has been researched.The results showed that joining H2O2 is better than not joining H2O2.The best value of each factors are as follows: when the H2O2 dosage is 0.15 mg/L,filtration rate is 8 m/h,pH is 7,the particle size of Quartz sand is 1.0 mm,the maximal Mn2+ removal efficiency can be reached 90.7%.