The blockage of emitters is a key factor affecting the quality of water drip irrigation with the Yellow River water. This article focuses on the flow rate changes and clogging effects of different types of drip irrigation emitters in Yellow River water irrigation. The blockage simulation experiments were conducted on eight different drip irrigation emitters and three sediment concentrations of 1 ‰ (1 kg/t), 2 ‰ (2 kg/t), and 4 ‰ (4 kg/t). The results show that the flow attenuation rate increases with the increase of irrigation time, and the overall attenuation rate reaches 43% to 72% after 300 hours of irrigation. Furthermore, the flow attenuation rate also increases with the increase of sediment concentration, the emitters with low sediment content (1‰) of 75% exhibit moderate blockage; whereas those with high sediment content (4‰) of 100% exhibit severe blockage. The irrigation uniformity of emitter N-1.6 and N-2.0B under three different sediment concentrations are all above 80%, which can meet the irrigation needs of crops. The flow attenuation of the emitter is positively correlated with the length of the flow channel in the emitter. As the length of the channel increases, the anti-clogging performance of the emitter decreases, and the flow——attenuation increases. The sediment d50 in the flow channel is negatively correlated with the design flow velocity of the emitter, which decreases with the increase of the design flow velocity. The sediment volume ratio of particle size of 0~30 μm inside the flow channel decreases with the increase of the sediment concentration. The research results can provide reference for solving the problem of drip irrigation emitters clogging with the Yellow River water.