Reclaimed water is called the second water source of city; strengthening the allocation and utilization of reclaimed water is conducive to optimizing the water supply structure, increasing the supply of water resources, alleviating the contradiction between water supply and demand, and ensuring water ecological security. Scientific demand prediction of urban reclaimed water can provide a technical support for the improvement of wastewater resource utilization level. Based on the demand analysis of regional water resources, full consideration is given to the characteristics of quantity and quality of water demand in 4 fields, including industrial production use, urban miscellaneous use, river replenishment use, as well as farmland and forestry irrigation use. Then, a technical framework of demand prediction of reclaimed water in various fields is put forward based on the consideration of water quality and water price. Firstly, considering the influence of water quality, the index of the replaceable rate of reclaimed water is introduced to analyze the water quantity that can be supplied by reclaimed water in the total water demand. Secondly, considering the influence of the price on the demand of reclaimed water under the independent pricing mode, a subsidy-price-demand model is established to calculate regional reclaimed water demand under different subsidy scenarios. The case study of the central urban area of Suqian City show that under the requirements of the target utilization rate of reclaimed water in 2025 and 2030, the medium subsidy scenario can effectively promote the utilization of reclaimed water while balancing the financial pressure of the government, and the reclaimed water demand can reach 10 095×104 and 13 387×104 m3 respectively. This study provides a new addition to the theoretical methods of the demand prediction of urban reclaimed water, as well as a technical support for the utilization and allocation of reclaimed water in Suqian City.