To promote the application of acid aggregates in hydraulic asphalt concrete panels, the effects of different acid aggregates and asphalt viscosity enhancement schemes on the key properties of asphalt concrete panels were studied, and the optimal acid aggregate and asphalt viscosity enhancement scheme were evaluated comprehensively using the variation coefficient TOPSIS method. The results showed that all five different viscosity enhancement schemes improved the water damage resistance of the granite asphalt concrete to different degrees, and the water stability coefficient and slope flow value all met the specification limits. According to the analysis of the effect of water damage on various properties of asphalt concrete, the compressive strength was the least sensitive to water damage, whereas the flexural strain and slope flow value were the most sensitive. Variation coefficient TOPSIS comprehensive evaluation results showed that limestone asphalt concrete had the optimal comprehensive performance; the addition of anti-spalling agent could increase the resistance of granite asphalt concrete to water damage by 18%～25% which was optimal for increasing the adhesion between the aggregate and the asphalt, but non-amine anti-spalling agent could lead to a larger deformation of the asphalt concrete. Therefore, the subsequent study of the application of acid aggregates in asphalt concrete panels should focus on its deformation performance.