Xiangjiaba Hydropower Station is mainly used for power generation, but its operation is mandated by the requirement of safe flow pattern in the navigation channel. According to the statistical characteristics of the typical daily load of the East China Power Grid, taking into account the operating characteristics of the unit and the requirements of the hourly and daily variation amplitude of the water level, we drew up five kinds of daily power regulation flow for Xiangjiaba Hydropower Station based on the actual water flow conditions. A two-dimensional hydrodynamic model was used to reveal the flow pattern at the entrance of the downstream navigation channel when the station was operating at different power generation flows. MIKE21 was used to solve the model and two feasible scheduling modes were selected from indicators including the channel’s lateral flow velocity, longitudinal flow velocity, water level variation amplitude and return flow conditions. Finally, by comparing the daily power generation of the two operational conditions, we ascertained the most suitable scheduling mode for Xiangjiaba Hydropower Station. According to this mode, with an average output of 2, 914 MW, Xiangjiaba Hydropower Station can reach a daily power generation of 72.85×106 kW·h.