Taking eight cities in the Anhui section of the Huaihe Eco-economic Belt as the research objects, a comprehensive index system for evaluating the sustainability of water resources is constructed based on the PSR (pressure-state-response) model. The weight of each index is determined by the ideal point method, and then the normal cloud model is introduced to evaluate its comprehensive development status, which is visualized by GIS software. The results show that the sustainability of water resources in the Anhui section of the Huaihe Eco-economic Belt showed an overall upward trend from 2010 to 2018, but it was still at a low level. The internal development of the region was not balanced, among which Fuyang and Lu’an City had reached Grade IV, but the rest of the cities were at Grade II or below. The response subsystem developed faster, the pressure and state subsystems were the main factors restricting the overall development of the region.