Studies on the contribution rates of climate change and human activities to the runoff variations of Baihe River Basin is valuable for the planning and management of water resources in this area. In this paper the Baihe River Basin was selected as the study area, linear trend method and moving average method were adopted to analyze the interannual trends of hydrometeorological elements. Then, Mann-Kendall test, sequential cluster test and moving t test were adopted to investigate the abrupt change year of the annual runoff. Finally, multiple water balance methods based on Budyko hypothesis were adopted to evaluate the influences of climate change and human activities on the runoff variations. Results show that the annual runoff in Baihe River Basin showed a downward trend, the average runoff from 2008 to 2017 only reached 36.5% of that from 1960 to 1969. The abrupt change of annual runoff happened in 1979 and the annual runoff showed a significant downward trend after 1986. Compared to the base period, the drought index increased in the variation period and the droughts became more severe from 2001 to 2017. Human activities was the major cause of runoff variations, its average contribution rates to the runoff variations were 85.6% and 73.6% for the periods of 1980-2000 and 2001-2017 respectively, which also indicate that the influences of climate change on the runoff variations were on the rise.