Different guide vane closure ways have great influence on pressure value and pressure distributing characteristics of the flow passage during the transient process of the hydropower station, especially for hydropower stations at dam toe with short penstock and large cross section, which may cause the uneven distribution of pressure on the same cross section and is harmful for the safety of hydropower station. To explore the effect of different guide vane closure laws on pressure spatial distributing characteristics of hydropower station at dam toe flow passage, this paper takes the Three Gorges Right Bank Hydropower Station, a typical hydropower station at dam toe, as the researching object, and uses three-dimensional numerical simulation along with self-defined Analysis on Pressure Distributing Characteristics Difference, to compare and study pressure spatial distributing characteristics within different guide vane closure law. The results showed that the maximum rotating speed will get restriction when applying three-stage guide vane closure law. The pressure distribution at the same cross section will be more even when applying two-stage guide vane law, which will beneficial to the flow passage and ensure the steady and safe operation of the hydropower station.