Aiming at solve the unreasonable exploitation and utilization of groundwater in the plain area of Mihe River Basin, we used the monitoring data of groundwater level from 1985 to 2015 to study the dynamic variation and distribution characteristics of groundwater depth in time and space and to analyze the influencing factors by correlation analysis and ordinary Kriging interpolation method. In addition, the overexploitation area was divided to evaluate the suitability of groundwater exploitation by combining the GIS and the water level dynamic method. The results showed that, the groundwater depth in the plain area of Mihe River Basin increased year by year due to the influence of climate change and human activities, and the groundwater level was the highest in February to March and the lowest in May to June. The spatial distribution of buried depth was affected by topography, decreasing from southwest to northeast. A small range of funnel appeared at the junction of Qingzhou and Shouguang in 1995, and the buried depth of groundwater in the center of funnelwas increasing year by year. By 2015, the suitable mining areas in the study area was mainly distributed in Shouguang, Qingzhou, Linqu and other cities, with an area of 710.2 km2, accounting for only 21.0% of the total area.