In order to study the effects of different irrigation quotas and nitrogen application rates on water consumption of melon in northern Xinjiang, a 2-year field experiment of melon irrigation was carried out at Altay Irrigation Experimental Station from 2016 to 2017.In 2016, five different irrigation quotas were set at 300 m3/hm2, 375 m3/hm2, 450 m3/hm2, 525 m3/hm2 and 600 m3/hm2 respectively. In 2017, three different irrigation quotas were set up to 300 m3/hm2, 450 m3/hm2 and 600 m3/hm2 respectively. Three different nitrogen rates were 0, 138 kg/hm2 and 276 kg/hm2, respectively. The results showed that: Under different irrigation quotas and water-nitrogen interaction, the change law of average water consumption in ten days of watermelon-beating showed the law of first increasing and then decreasing. Water consumption, water consumption intensity and water consumption modulus during fruit expansion increased with the increase of irrigation quota. The crop coefficient increased with the increase of irrigation quota, and changed from 0.360 to 0.431, among which 600 m3/hm2 irrigation quota had the largest water consumption, water consumption intensity and crop coefficient. Suitable water and nitrogen supply increased water consumption modulus, crop coefficient, water consumption and water consumption intensity, and crop coefficient varied from 0.317 to 0.445. Compared with other growth stages, different irrigation quotas and water-nitrogen interaction had the greatest impact on water consumption, water consumption intensity and crop coefficient during fruit expansion stage. The study can provide a basis for understanding the water consumption characteristics of the field and the water-saving and efficient production of local melon.