Based on the principle of seepage, the formula of the influence coefficient of coal mining on water resource in Yushen Mining Area was derived, and the zoning methods and criteria for impact levels were proposed. Through statistical analysis of drilling data, 528 influence coefficients were calculated. Considering the hydrogeological conditions, the impact levels of coal mining on water resources in YuShen Mining Area was divided into three categories: no water area, indirect impact area and direct impact area, with an area of 836 km2, 3668 km2 and 761 km2 respectively, accounting for 15.88%, 69.67% and 14.45% of the total mining area. Furtherly, they were divided into several subareas. According to the measured data of inrush water, the location of the high water yield mines is consistent with the results of this zoning, which proves that the zoning methods and standards are correct and feasible, and they can be used in areas with similar hydrogeological conditions. Finally, based on the drainage characteristics of typical coal mine and the influences on water resource, several suggestions on water resource protection for coal mining were proposed.