According to the characteristics of precipitation and the groundwater depth data of 67 monitoring wells from 1984 to 2014, a geo-statistical method was used to analyze the spatial variability and change rules in Jilin urban area. The result shows that the spatial correlation of groundwater depth in the urban area increases gradually and the groundwater depth is of moderate spatial correlation from 1984 to 1999, whereas from 2000 to 2014 spatial correlation is intensive. The maximum spatial correlation distance between 1984 and 1999 is relatively small. The spatial autocorrelation distance in 1984 and 1999 is less than that in other years, leading to a poor spatial continuity of groundwater depth during this period. Anisotropy ratio decreases over time in generally, which indicates that the spatial anisotropy of urban groundwater depth is increasing gradually. Kriging interpolation result shows that the groundwater depth of the study area changes with terrain elevation and water source regions' distribution, and the result also presents a dynamic changing process in the influence of mining intensity. The groundwater depth of subsiding center tend to stabilize in recent years.